[Predictive role of self-efficacy, belief of treatment effectiveness and social support in diabetes mellitus self-management]

The aim of this research was to study the predictive role of self-efficacy, belief of treatment effectiveness, social support and doctor-patient relationship on diabetes Mellitus self-management. 500 type II diabetes outpatients [245 men and 255 women] presenting to Shariati Hospital in Tehran were selected by convenience sampling. The subjects completed the scales related to diabetic self-care, self-efficacy, belief of treatment effectiveness, social support and doctor-patient relationship. Data were analyzed using Pearson correlation coefficient and multiple regression analysis. There was a significant and positive relationship between self-efficacy, belief of treatment effectiveness, doctor-patient relationship, social support and diabetes self-management [p<0.001]. Self-efficacy, belief of treatment effectiveness and social support were capable of predicting diabetes self-management variance significantly [F=1.326, df=3 and 310, p<0.001] and explain 89% of diabetes self-management. Belief of treatment effectiveness, social support and especially, self-efficacy, are important self-management activities in diabetes Mellitus. Therefore, provision of improvement and enrichment programs for self-efficacy, are helpful for the improvement of self-care behaviors and the reduction of diabetes Mellitus associated harm

BCL-2 associated athanogene-1 overexpression in diffuse large B-cell lymphoma

Apoptosis and cell cycle regulation play an important role in pathogenesis and tumor progression in patients with Diffuse Large B-Cell Lymphoma [DLBCL]. Bcl-2 associated athanogene-l [BAG-1] is an antiapoptotic protein as well as a regulator of cell growth. There is no conclusive evidence about BAG-i protein expression in this disease. To investigate the expression level of BAG-i protein in DLBCL. Methods: Thirty patients diagnosed from 1997-2004, as having DLBCL, were selected. Also 30 normal lymph nodes were included as normal counterparts in this study. BAG- 1 expression was determined by inmiunohistochemical staining in both DLBCL and normal lymph node samples. Of the 30 DLBCLs examined, 100% were positive for nuclear and 83% were positive for cytoplasmic BAG-1 staining. Of the 30 normal lymph nodes investigated, 20% were positive for nuclear and 0% were positive for cytopiasmic BAG-1 staining. Nuclear staining in DLBCL samples was significantly higher than those of normal lymph nodes [100% versus 20%, p < 0.001]. Besides, cytoplasmic staining in DLBCL samples was significantly higher than those of normal lymph nodes [83% versus 0%, p < 0.001]. There was no association between BAG-i staining and patients' overall survival. Our data indicated that BAG-i protein was deregulated in this disease similar to some other malignancies such as breast and colon cancer. Overexpression of BAG-I in DLBCL suggests that this protein probably plays an important role in the pathogenesis of DLBCL. Besides, higher nuclear BAG-1 staining might be correlated with poor prognosis

Study of relationship between p53 protein stability and pathological parameters in colorectal cancer by immunohistochemistry method

Genetic damages and dietary habits play important parts in colorectal cancer [CRC]. p53 protein, a product of p53 gene, is the most important tumor suppressor. The rate of p53 mutation and expression has been variously reported across anatomical regions. p53 protein has a short half-life which tends to increase with mutation and is likely to be traced by immunohistochemistry. This study is intended to determine the p53 protein stability by pathological parameters across different areas in CRC. This descriptive analytical research was conducted on 80 CRC cases admitted to Hospital in Isfahan, Iran from 2003 to 2007. p53 expression was detected by immunohistochemical methods in the samples after fixation, tissue processing and antigen retrieval. The obtained data were analyzed using chi-square. of the 80 specimens investigated, p53 protein stability was observed in 27 specimens [34%]. No significant relationships were observed between p53 protein stability and tumor staging, differentiation and anatomical regions [colon and rectum] but the relationship between protein stability and mutation was significant. p53 protein stability was observed in many mutated samples. Therefore, p53 protein detection in Cancer cases can be considered an important symptom of mutation signifying the prognosis and progress of cancer